Package: depower
Title: Power Analysis for Differential Expression Studies
Version: 2026.11.11
Authors@R: c(
    person(
      given = "Brett", 
      family = "Klamer", 
      email = "code@brettklamer.com", 
      comment = c(ORCID = "0000-0002-8334-4831"),
      role = c("aut", "cre")
    ),
    person(
      given = "Lianbo", 
      family = "Yu", 
      email = "lianbo.yu@osumc.edu", 
      comment = c(ORCID = "0000-0002-2025-2585"),
      role = c("aut")
    )
  )
Description: Provides a convenient framework to simulate data, run
        hypothesis tests, estimate power, and plot the results for
        differential expression studies. The simulation-based framework
        is described in Klamer and Yu (2026)
        <doi:10.1177/11769351261431247>. Outcomes may be lognormal,
        negative binomial, or bivariate negative binomial. Supported
        designs are one-sample, independent two-sample, and dependent
        two-sample comparisons. Built-in tests include t-tests, Wald
        tests, and likelihood ratio tests. User-defined tests are also
        accepted. The significance level can be set to control the
        per-family error rate or the family-wise error rate. Negative
        binomial methods are described in Yu, Fernandez, and Brock
        (2017) <doi:10.1186/s12859-017-1648-2> and Yu, Fernandez, and
        Brock (2020) <doi:10.1186/s12859-020-3541-7>.
URL: https://brettklamer.com/work/depower/,
        https://bitbucket.org/bklamer/depower/
License: MIT + file LICENSE
Depends: R (>= 4.5.0)
Imports: Rdpack, stats, mvnfast, glmmTMB, dplyr, multidplyr, ggplot2,
        scales
Suggests: tinytest, rmarkdown
RdMacros: Rdpack
Language: en-US
Encoding: UTF-8
Roxygen: list(markdown = TRUE)
Config/roxygen2/version: 8.1.1
Config/pak/sysreqs: cmake make libicu-dev
Repository: https://bklamer.r-universe.dev
Date/Publication: 2026-11-11 18:05:19 UTC
RemoteUrl: https://bitbucket.org/bklamer/depower
RemoteRef: HEAD
RemoteSha: b4057e799f40cc7787f2b7cf7ebeb7b8b91f6fb5
NeedsCompilation: no
Packaged: 2026-11-11 18:55:41 UTC; root
Author: Brett Klamer [aut, cre] (ORCID:
    <https://orcid.org/0000-0002-8334-4831>),
  Lianbo Yu [aut] (ORCID: <https://orcid.org/0000-0002-2025-2585>)
Maintainer: Brett Klamer <code@brettklamer.com>