Package: prsladder
Title: Polygenic Risk Scores and Time to Disease Progression
Version: 2026.9.23
Authors@R: c(
    person("Brett", "Klamer", email = "code@brettklamer.com", role = c("cre", "aut", "cph")),
    person("Ying", "Wang", email = "ying.wang@osumc.edu", role = c("aut", "cph"))
  )
Description: Measures the association of one or more polygenic risk
        scores with time to a disease event among persons who have a
        first diagnosis. Fits a ladder of Cox proportional-hazards
        models over all subsets of the scores, compares nested models,
        predicts absolute risk at a horizon with delayed entry, and
        evaluates discrimination, calibration, and reclassification.
        With competing events, fits cause-specific hazard models and
        estimates the cumulative incidence. Draws risk curves with risk
        tables, hazard ratios across the ladder, and calibration and
        discrimination, and makes tables of risk by score group.
        Estimates standardized risk at score percentiles, risk ratios,
        case shares, and time lost by score group, and net benefit.
        Includes a simulator with known hazard ratios.
URL: https://brettklamer.com/work/prsladder/,
        https://bitbucket.org/bklamer/prsladder/
License: MIT + file LICENSE
Depends: R (>= 4.5.0)
Imports: ggplot2 (>= 4.0.0), parallel, patchwork (>= 1.3.0), Rdpack,
        splines, stats, survival (>= 3.8-4), utils
Suggests: gtsummary (>= 2.6.1), knitr, rmarkdown, tinytest
RdMacros: Rdpack
Language: en-US
VignetteBuilder: knitr
Roxygen: list(markdown = TRUE)
Encoding: UTF-8
Config/roxygen2/version: 8.1.1
Repository: https://bklamer.r-universe.dev
Date/Publication: 2026-11-12 02:06:42 UTC
RemoteUrl: https://bitbucket.org/bklamer/prsladder
RemoteRef: HEAD
RemoteSha: 8a3ab90edd531424f62473f2df6e4d988b1d53d0
NeedsCompilation: no
Packaged: 2026-11-12 03:16:07 UTC; root
Author: Brett Klamer [cre, aut, cph],
  Ying Wang [aut, cph]
Maintainer: Brett Klamer <code@brettklamer.com>