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cff-version: 1.2.0
message: 'To cite package "prsladder" in publications use:'
type: software
license: MIT
title: 'prsladder: Polygenic Risk Scores and Time to Disease Progression'
version: 2026.9.23
doi: 10.32614/CRAN.package.prsladder
abstract: Measures the association of one or more polygenic risk scores with time
  to a disease event among persons who have a first diagnosis. Fits a ladder of Cox
  proportional-hazards models over all subsets of the scores, compares nested models,
  predicts absolute risk at a horizon with delayed entry, and evaluates discrimination,
  calibration, and reclassification. With competing events, fits cause-specific hazard
  models and estimates the cumulative incidence. Draws risk curves with risk tables,
  hazard ratios across the ladder, and calibration and discrimination, and makes tables
  of risk by score group. Estimates standardized risk at score percentiles, risk ratios,
  case shares, and time lost by score group, and net benefit. Includes a simulator
  with known hazard ratios.
authors:
- family-names: Klamer
  given-names: Brett
  email: code@brettklamer.com
- family-names: Wang
  given-names: Ying
  email: ying.wang@osumc.edu
repository: https://bklamer.r-universe.dev
repository-code: https://bitbucket.org/bklamer/prsladder/
commit: 9ec3ca71663062c3ef43efd054d56408a7d0be29
url: https://brettklamer.com/work/prsladder/
date-released: '2026-11-12'
contact:
- family-names: Klamer
  given-names: Brett
  email: code@brettklamer.com